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Scientific References

Every ingredient in Yu Sleep is backed by published research. Here are the peer-reviewed studies.

Last updated: January 1, 2026

Yu Sleep is built on a foundation of published, peer-reviewed scientific research. Every ingredient in our formula has been studied in clinical trials, meta-analyses, or systematic reviews indexed in PubMed and other reputable medical databases.

Below is a curated list of scientific references supporting each ingredient in Yu Sleep. We encourage you to review these studies and discuss them with your healthcare provider.

Red Tart Cherry Extract

  1. Howatson G, et al. (2012). Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality. European Journal of Nutrition.
  2. Losso JN, et al. (2018). Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia in Older Adults. American Journal of Therapeutics.
  3. Pigeon WR, et al. (2010). Effects of a tart cherry juice beverage on the sleep of older adults with insomnia. Journal of Medicinal Food.

5-HTP (5-Hydroxytryptophan)

  1. Sutanto CN, et al. (2024). The impact of 5-hydroxytryptophan supplementation on sleep quality. Sleep Medicine Reviews.
  2. Bruni O, et al. (2004). L-5-Hydroxytryptophan treatment of sleep terrors in children. European Journal of Pediatrics.
  3. Meloni M, et al. (2021). Preliminary finding of a randomized, double-blind, placebo-controlled trial of 5-HTP in Parkinson's disease. Movement Disorders.

Vitamin B6 (Pyridoxine)

  1. Aspy DJ, et al. (2018). Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dream Recall and Dream Vividness. Perceptual and Motor Skills.
  2. Liu H, et al. (2024). Vitamin B6 alleviates chronic sleep deprivation-induced ferroptosis. Free Radical Biology and Medicine.

Vitamin B2 (Riboflavin)

  1. National Library of Medicine. Riboflavin (Vitamin B2): Overview, Sources, and Function. StatPearls.
  2. Grandner MA, et al. (2018). The Association Between Dietary Vitamin B2 Intake, Sleep Quality, And Daytime Alertness. Sleep.

Magnesium Glycinate

  1. Abbasi B, et al. (2012). The effect of magnesium supplementation on primary insomnia in elderly. Journal of Research in Medical Sciences.
  2. Mah J, et al. (2021). The effect of magnesium on sleep quality in adults: a systematic review. BMC Complementary Medicine and Therapies.

Apigenin

  1. Salehi B, et al. (2019). The therapeutic potential of apigenin. International Journal of Molecular Sciences.
  2. Mao JJ, et al. (2016). Long-term chamomile (Matricaria chamomilla) extract therapy for generalized anxiety disorder. Phytomedicine.

Lemon Balm Extract (Melissa officinalis)

  1. Cases J, et al. (2011). Pilot trial of Melissa officinalis L. leaf extract in mild to moderate anxiety disorders and sleep disturbances. Mediterranean Journal of Nutrition and Metabolism.
  2. Haybar H, et al. (2015). The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep. Clinical Nutrition ESPEN.

L-Theanine

  1. Lyon MR, et al. (2011). In Search of a Safe Natural Sleep Aid. Journal of the American College of Nutrition.
  2. Dasdelen MF, et al. (2022). A Novel Theanine Complex, Mg-L-Theanine Improves Sleep Quality. Frontiers in Nutrition.
  3. Kim S, et al. (2019). GABA and l-theanine mixture decreases sleep latency and improves NREM sleep. Pharmaceutical Biology.

GABA (Gamma-Aminobutyric Acid)

  1. Hepsomali P, et al. (2020). Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep. Frontiers in Neuroscience.
  2. Gottesmann C. (2002). GABA mechanisms and sleep. Neuroscience.

Melatonin (Low Dose)

  1. Salehpour F, et al. (2021). Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis. Sleep Medicine.
  2. Ferracioli-Oda E, et al. (2013). Meta-analysis: melatonin for the treatment of primary sleep disorders. PLOS One.
  3. Givler D, et al. (2022). Melatonin in sleep disorders. Cureus.

Combined Sleep Formulas

  1. Maroo N, et al. (2019). A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia. Indian Journal of Medical Research.
  2. Smith J, et al. (2024). Current Evidence on Common Dietary Supplements for Sleep Quality. Nutrients.

Important Note

Disclaimer: The scientific references provided above are for informational and educational purposes. They support the rationale for including specific ingredients in Yu Sleep but do not constitute clinical evidence that Yu Sleep itself has been proven to produce specific results. Yu Sleep has not been independently studied as a finished product, and individual results may vary. Always consult your healthcare provider before starting any new dietary supplement.

Questions About the Research?

If you have questions about the scientific basis for any Yu Sleep ingredient, our team is happy to help. Contact us at support@yu-sleep.com.